Various medications are used during pregnancy despite a lack of data in this unique setting. This review will describe basic concepts in pharmacokinetics and their clinical relevance and highlight the variations in pregnancy that may impact the pharmacokinetic properties of medications. Furthermore, over two-thirds of women receive prescription drugs while pregnant, with treatment and dosing strategies based on data from healthy male volunteers and non-pregnant women, and with little adjustment for the complex physiology of pregnancy and its unique disease states. Unfortunately, most drug studies have excluded pregnant women based on often-mistaken concerns regarding fetal risk. Understanding both pregnancy physiology and the gestation-specific pharmacology of different agents is necessary to achieve effective treatment and limit maternal and fetal risk. It follows that detailed pharmacologic information is required to adjust therapeutic treatment strategies during pregnancy. ![]() Similarly, variations in physiology may alter the pharmacokinetics or pharmacodynamics that determines drug dosing and effect. These adaptations may affect preexisting disease or result in pregnancy-specific disorders. Pregnancy is a complex state where changes in maternal physiology have evolved to favor the development and growth of the placenta and the fetus.
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